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Pickart and Margolina (2018) review documents broad gene-expression effects in vitro

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Comparing outcomes from a localized SubQ injection (lumbar/glute) versus a distant SubQ injection (abdomen) can yield powerful data on the compound's site-enhancement effects

The current 4-week-per-dose-level schedule was specifically designed to minimize GI side effects while reaching therapeutic doses in a reasonable timeframe

B12 injections involve administering a concentrated dose of vitamin B12 directly into the bloodstream

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